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Written by Dee Mani on 25 August 2025

Ozempic and Mounjaro Side Effects - And Natural Ways to Support Your Health

The Hype vs The Hidden Truth

If you’ve opened social media lately, you’ll know Ozempic and Mounjaro are being hailed as “miracle weight-loss drugs.” Celebrities whisper about them, influencers flaunt their slimmed-down bodies, and doctors are writing prescriptions like they’re handing out candy.

But here’s the actual truth: these drugs aren’t miracles - they’re pharmaceutical products with both benefits and risks that are still being studied. And people lining up for the quick fix are now reporting potential side effects that are often under-discussed.

If you’re tempted by the hype, pause. Because while the headlines scream “weight-loss wonder,” the small print — and the patient experiences — tell another story.

What Are Ozempic and Mounjaro?

Ozempic (semaglutide) and Mounjaro (tirzepatide) belong to a class of drugs called GLP-1 receptor agonists. They were originally designed for type 2 diabetes, helping to control blood sugar by mimicking a hormone that regulates insulin and appetite.

But pharma saw another market: weight loss. By slowing digestion and signaling satiety, these drugs reduce appetite, which may result in weight loss. That’s the sales pitch anyway.

The reality? Altering your body’s hunger signals can have a range of effects, both intended and unintended.

The Side Effects Nobody Wants to Talk About

1. Gastrointestinal Chaos

The most common side effects are nausea, vomiting, diarrhea, constipation, and stomach pain. Some users report gastroparesis — essentially, a paralyzed stomach. Food sits there, not moving, causing bloating, reflux, and even vomiting hours after eating.
👉 A 2023 JAMA database study reported a higher observed risk of gastroparesis among users of GLP-1 drugs like Ozempic compared to users of another weight-loss medication.

2. Gallbladder and Pancreas Issues

GLP-1 drugs increase risk of gallbladder disease (including gallstones) and pancreatitis — painful, dangerous inflammation of the pancreas. The FDA already includes these warnings on the drug labels.

3. Thyroid Cancer Warnings

Animal studies have suggested a possible link between GLP-1 drugs and thyroid changes. This has not been confirmed in humans, but the warning appears on prescribing information for caution. While not yet proven in humans, the warning is strong enough that anyone with thyroid history is told to avoid them.

4. Mental Health and Eating Disorders

By chemically suppressing appetite, people can develop disordered eating patterns, food anxiety, and even malnutrition. There’s also emerging research linking GLP-1 drugs with worsened depression in some patients.

5. Cosmetic Oddities: “Ozempic Face,” “Ozempic Feet”

Rapid weight loss doesn’t just melt fat — it accelerates skin sagging, aging, and muscle loss. Recently, “Ozempic feet” (painful, thinning foot pads) and “Ozempic vulva” have even gone viral on TikTok as people share bizarre physical changes.

6. Emergency Room Visits Are Rising

A 2025 study reported a notable increase in ER visits among GLP-1 weight-loss drug users in the U.S.

So yes, people are losing weight. But they’re also ending up in hospital beds.

Mounjaro vs Ozempic: Is One Safer?

Short answer: no.

Mounjaro (tirzepatide) is often hyped as “the stronger cousin” of Ozempic, targeting two gut hormones instead of one. While this may speed weight loss, it also amplifies side effects — especially nausea and GI distress.

There’s no free ride. These drugs manipulate the same fundamental pathways and carry the same long-term unknowns.

The Quick Fix That Fixes Nothing

Even if you manage to dodge the serious side effects, here’s the reality:

  • Weight often rebounds once the injections stop. Studies show most people regain two-thirds of their weight within a year of discontinuing GLP-1 drugs.
  • Your metabolism doesn’t “reset” - it adapts to forced calorie restriction.
  • Some evidence suggests metabolism may adapt to calorie restriction, which can make weight maintenance more challenging after discontinuation.

This is classic pharma strategy: sell you a drug that manages symptoms, but often requires long-term use.

What You Should Be Doing Naturally Instead

So, what’s the alternative? No, it’s not about another fad diet or starving yourself. It’s about supporting your body’s natural systems so weight and metabolic health improvements may follow naturally as part of overall wellbeing.

1. Focus on Metabolic Balance, Not Starvation

  • Eat whole foods rich in protein, healthy fats, and fiber.
  • Cut ultra-processed junk that drives insulin spikes and cravings.
  • Think quality, not calorie.

2. Fibremaxxing — The TikTok Trend That Actually Works

Unlike Ozempic, which chemically slows digestion, fiber and healthy fats naturally support satiety and gut health. Increasing intake of beans, organic oats, flaxseeds, and veggies feeds your microbiome, balances blood sugar, and keeps you full longer. Pair this with nourishing fats like avocado, olive oil, nuts, seeds, and even coconut oil (which can be taken straight from the jar), and you’ll feel satisfied without needing a pharmaceutical crutch. Together, fiber and healthy fats keep your metabolism steady, reduce cravings, and support sustainable weight management.

3. Movement That Heals

You don’t need to run marathons. Walking, strength training, yoga, and even the viral 6-6-6 walking routine (60 minutes brisk walk a day) all improve insulin sensitivity and fat burning without wrecking your gut.

4. Nervous System Repair

Chronic stress drives overeating and belly fat via cortisol. Practices like breathwork, cold exposure, vagus nerve stimulation, and yes — CBD — all help regulate stress responses.

5. CBD: The Overlooked Ally in Weight Management

Research shows CBD influences the endocannabinoid system, which regulates appetite, energy balance, and fat metabolism source

  • Insulin sensitivity: A study in American Journal of Pathology (2016) found cannabinoids reduce insulin resistance.
  • Inflammation: CBD calms systemic inflammation, a driver of obesity.
  • Appetite regulation: Unlike THC, which increases appetite, CBD helps normalize hunger cues — reducing emotional overeating.

CBD isn’t a “magic bullet,” but unlike pharmaceutical injections, it is being studied for how it may support the body’s own regulatory systems.

👉 At My Way CBD, we see clients use our Full Spectrum CBD oils to improve sleep, reduce stress eating, and support their metabolism naturally.

Why This Matters

Obesity and metabolic disease are complex. But the solution will never be a weekly jab that overrides your biology. The solution is root-cause repair: healing the gut, calming the nervous system, balancing hormones, and reducing toxic load.

Pharma’s job is to keep you on the hook. My job — and your job — is to take back control.

Don’t Trade One Trap for Another

Ozempic and Mounjaro promise quick fixes. But behind the glossy marketing are serious side effects, long-term unknowns, and a business model built on dependency.

Instead of outsourcing your health to an injection, start supporting your body naturally: more fiber, movement, nervous system repair, and metabolic allies like CBD.

Because the truth is, you don’t need a drug to be “fixed.” You need to stop treating your body like the enemy, and start working with it.

👉 Ready to support your metabolism without risking your health? Explore our Full Spectrum CBD oils and download our free Illness Prevention eBook today. Your healing starts with balance — not a syringe.

Written by Dee Mani

Dee Mani is the founder of My Way CBD, author of the bestselling book My Way, and a natural health consultant. Following a diagnosis of Triple Negative Breast Cancer in 2017, Dee chose a holistic approach focused on nutrition, lifestyle change, emotional wellbeing and plant medicine. After making a full recovery, she dedicated her life to helping others better understand the body, the endocannabinoid system, and the lifestyle factors that influence long-term health. Today, Dee educates thousands of people worldwide on CBD, cannabis, nervous system health, inflammation, hormones, trauma, nutrition and disease prevention. Through her writing, speaking and educational work, she is helping to change the conversation around natural health, personal responsibility and the body's remarkable ability to heal and maintain balance. Visit www.deemani.com to learn more.

FAQs on Ozempic, Mounjaro, and Natural Weight-Loss Alternatives

Q. What are the most common side effects of Ozempic and Mounjaro?

A. The most reported side effects include nausea, vomiting, diarrhea, constipation, and stomach pain. Some reports describe gastroparesis (slowed stomach emptying), gallstones, or pancreatitis as possible side effects. Rapid weight loss can also lead to “Ozempic face” (sagging skin) and muscle loss.

Q. Can Ozempic and Mounjaro cause long-term health issues?

A. Research suggests that while these drugs can aid weight loss, they may also carry risks including gallbladder issues, pancreatitis, and potential thyroid effects in animals. Long-term outcomes are still being studied.

Q. Are Ozempic and Mounjaro safe if I don’t have diabetes?

A. These drugs were developed for type 2 diabetes management. Using them off-label for weight loss may involve additional risks and does not address underlying contributors such as diet, stress, gut health, or inflammation.

Q. Do you regain weight after stopping Ozempic or Mounjaro?

A. Most people do. Clinical trials indicate that many people regain a significant portion of lost weight within a year of stopping treatment.

Q. What are natural alternatives to Ozempic and Mounjaro?

A. Natural approaches people explore include fiber-rich foods, healthy fats, regular movement, stress management, and supportive tools like CBD.

Q. How can CBD support weight management naturally?

A. Early research suggests CBD may influence the endocannabinoid system, which plays a role in appetite, metabolism, and stress responses. Unlike THC, it does not typically increase appetite.

Q. Is CBD safe compared to weight-loss injections?

CBD is generally considered well-tolerated and non-addictive, though it may interact with medications. Always choose high-quality, lab-tested CBD products and consult a professional if you’re on prescriptions.

Disclaimer: This article is for educational and informational purposes only and does not constitute medical advice. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. If symptoms persist, worsen, or you have concerns about your health, please consult a qualified healthcare professional.


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Written by Dee Mani on 25 August 2025
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